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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They may be unusual In this particular malignancy when compared to other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A can also be mutated in a small proportion of sufferers